DL: dCod 1.0 -decoding systems toxicology of cod (Gadus morhua) -environmental genomics for ecosystem quality monitoring and risk assessment
Informations
- Funding country
Norway- Acronym
- -
- URL
- -
- Start date
- 1/1/2016
- End date
- 12/31/2021
- Budget
- 4,727,136 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| BIOTEK2021 - Biotechnology for value creation | Grant | - | - | 4,727,136 EUR |
Abstract
The Atlantic cod (Gadus morhua) is an important species in North Atlantic fisheries, as well as coastal and pelagic ecosystems. It is also a widely used indicator species in European monitoring programs. The goal of the dCod 1.0-project was to combine competencies in environmental toxicology, biology, bioinformatics and mathematics across the traditional department boundaries, to create a deeper understanding of the Atlantic cod's adaptations and reactions to stressors in the environment. Building on thorough studies and mapping of the cod genome and long research traditions on the physiology, toxicology and reproduction biology of cod, the dCod project has expanded our knowledge with genomics based methods, with studies of how the cod genome responds under different environmental conditions. In dCod 1.0 we have generated large amounts of experimental results and data using in silico (defensome modelling and metabolic reconstruction), in vitro (luciferase reporter assays with cod nuclear receptors and aryl hydrocarbon receptors), ex vivo (precision-cut liver slices), aquaria and field studies, as data sets for bioinformatics analyses and mathematical models that can describe responses based on different scenarios. Overall, the ambition has been to create a knowledge-base and a tool for environmental monitoring and risk assessment. The project has involved several lab and field studies, large and comprehensive omics analyses, and transdisciplinary activities.