The genetic background of neurocognitive dysfunction in psychiatric disorders
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 10/1/2010
- End date
- 9/30/2012
- Budget
- 25,220 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Postdoctoral Programme | Grant | 10/1/2010 | 9/30/2012 | 25,220 EUR |
Abstract
Research targeting the genetic background of neurocognition has traditionally followed different methodological pathways. The investigations of genetic abnormalities resulting in mental retardation, twin studies, and animal models have expanded our knowledge about the genetic effects influencing neurocognition. However this body of research has not been successful in the fine-mapping of complex, interactional effects of several genetic variants. In our proposal we follow an additional methodological approach, by investigating the genetic background of cognitive dysfunction observed in psychiatric disorders. Schizophrenia, bipolar disorder and attention-deficit hyperactivity disorder (ADHD) are clinically divergent psychiatric disorders, while they all demonstrate a high level of heritability, moreover neurocognition is affected in all of these conditions to some extent. Based on our previous research we plan the analysis of the clinical, neuropsychological and genetic data of 450 schizophrenic, 250 bipolar, 200 adult ADHD patients, and 300 healthy controls. We will aim to reproduce the association of previously studied risk variants with the diagnostic groups, moreover we will test the effect of these variants on cognitive functions. Besides looking at common variants (single nucleotide polymorphisms) we plan to analyse the association of rare variants (copy number variants, CNVs) with neurocognition. Such research promotes are understanding of the molecular architecture of psychiatric disorders and the genetic background of cognition.