Studying the inheritance of scale pattern and other linked traits of fishes
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 4/1/2009
- End date
- 3/31/2012
- Budget
- 58,599 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 4/1/2009 | 3/31/2012 | 58,599 EUR |
Abstract
This proposal outlines a novel approach to understand the genetic and developmental basis underlying variation in scalation in the common carp and closely related species, goldfish and zebrafish. The proposed project will be carried out by a trilateral international collaboration. Our preliminary experiments show, that the genetics of scale formation of carp can not be described by the formerly accepted model. Recently Harris and his colleagues were successful in isolating a mutant zebrafish, called ’spiegel’, with a mirror scalation phenotype astonishingly similar to the mirror phenotype in common carp and also in goldfish. This mutant is linked to a partial loss of function of a developmentally important gene, fibroblast growth factor receptor 1 (fgfr1). We found this gene with similar function in carp as well. We plan surveying the factors - supposedly of the same origin - effecting on the scalation pattern of these three fish species, applying special informative crosses, uniparental (gyno- or androgenic) propagation and molecular biological methods. We will test the effect of the fgfr mutations on production parameters of common carp, as growth, survival or resistance. We will initiate the search for the ’N’ (nude) gene. Finally we will set up a new model describing the scalation pattern in common carp and goldfish.