The role of genetic instability of aberrant hypermutation
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 2/1/2005
- End date
- 12/31/2007
- Budget
- 23,733 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 2/1/2005 | 12/31/2007 | 23,733 EUR |
Abstract
The somatic hypermutation occur in the CD19+ and CD38+ cells of the germinal centers by the expression of 'activation induced cytidine deaminase' (AID). The somatic hypermutation is a characteristic feature of the physiological B-cell maturation of the germinal center, but it is missing in the pre-follicular and post-follicular B-cells. Based on recent publications we assume, that continuous somatic hypermutation (aberrant hypermutation) and high level of AID expression are responsible for the genetic instability and development of different B-cell non-Hodgkin lymphomas (NHL). The aim of the study to determine whether aberrant hypermutation and AID expression play a role in the development of de novo diffuse large B-cell lymphomas and in the lymphoma transformation.