Etiology of idiopathic scoliosis
Informations
- Funding country
Hungary- Acronym
- -
- Start date
- 2/1/2003
- End date
- 12/31/2006
- Budget
- 27,425 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 2/1/2003 | 12/31/2006 | 27,425 EUR |
Abstract
The characteristics of idiopathic scoliosis are the co-existing of the followings: bending in the frontal plane, antero-posterior deviation creating lordosis in the sagittal plane and vertebral rotation around an axial pivot in the horizontal plane. The appearance of this spinal deformity is identical with the phenomenon of 'twisting external bend', a term used in physics and architecture. A rod compressed axially does not only deviate laterally but the cross-sections at different levels rotate around a longitudinal axis. The development of this event depends on the relation between the quality of the rod and the magnitude of the applied forces. Based on this theoretical approach the development of the idiopathic scoliosis is supposed to happen in the same manner by action of similar biomechanical forces. The change in the vertebral bone quality and the decrease of its mechanical resistance are postulated as a contributing factor in the formation of the spinal deformity. The vertebral bone will be described as follows: measurement of the bone density in the lumbar spine, serum and urine laboratory measurements to investigate the bone metabolism, bone histomorphometry. Curve measurements will be performed, too. Simultaneously, genetic surveys will be executed. Those genetic variables will be put under the loop which act either through influencing the qualitative/quantitative bone parameters or play per se a crucial role in the etiology of idiopathic scoliosis.