The role of nitric oxide in renal diseases
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 2/1/2003
- End date
- 12/31/2006
- Budget
- 17,808 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 2/1/2003 | 12/31/2006 | 17,808 EUR |
Abstract
Renal ischemia/reperfusion (I/R) injury leading to acute renal failure continues to be an important clinical problem, especially where the kidney is subjected to periods of warm ischemia, such as suprarenal aortic surgery and renal transplantation. The initial ischemic injury of the kidney is one of the most important risk factor for chronic allograft dysfunction. We have recently shown that gender and sex hormones influence I/R injury in the kidney. Recently nitric oxide (NO) was described as one of the most important mediator in the progression of different renal diseases. In I/R induced acute renal failure inducible nitric oxide synthase (iNOS) plays a central role, producing NO which can immediately act with oxidative agents generating vasoconstrictive peroxynitrite and isoprostane. These vasoactive mediators decreasing renal blood flow and causing the progression of acute renal failure. However, we have no data about the role of the other two NOS isoforms, the endothelial and neuronal NOS (eNOS and nNOS) in I/R induced acute renal failure. In our experiments we will investigate the role of different NOS isoenzyms and the oxidative stress in I/R induced acute renal failure and chronic allograft dysfunction in different gender.