Chaperones and cytoskeleton
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 2/1/2002
- End date
- 12/31/2005
- Budget
- 42,930 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 2/1/2002 | 12/31/2005 | 42,930 EUR |
Abstract
The research project is based on a hypotheses published by the principal investigator in 2001. The hypotheses propose novel roles for molecular chaperones. Chaperones may participate in the organization of the cytoplasm and buffer several mutations in living cells by correcting the folding damage caused by amino acid changes. This maintenance of the cellular phenotype is severly compromised in aged organisms, where damaged proteins become abundant, and efficiently compete with the silent mutations. The following research areas are planned to be investigated: 1. We will elucidate the role of chaperones in cytoplasmic organization. 2. We will examine signaling after the “poisoning” of chaperones by damaged proteins as well as after the selective inhibition of the Hsp90 chaperone at its novel nucleotide binding site discovered in our laboratory.