Sexual differentiation
Informations
- Funding country
Hungary- Acronym
- -
- URL
- -
- Start date
- 2/1/2002
- End date
- 12/31/2005
- Budget
- 26,370 EUR
Fundings
| Name | Role | Start | End | Amount |
|---|---|---|---|---|
| Thematic Programme | Grant | 2/1/2002 | 12/31/2005 | 26,370 EUR |
Abstract
Sexual differentiation involves a cascade of events initiated by the presence of the SRY gene on the Y chromosome, which causes the indifferent gonad to develop into a testis. Hormonal products of the testis control the sexual differentiation of the developing fetus. Testosterone is necessary for masculinization of external genitalia. The androgen receptor mediates the action of testosterone. Lack or abnormality of SRY gene result in gonadal dysgenesis. Mutations of the androgen receptor gene cause undermasculinization of the genetic male fetus.